LABORATORY OF PHARMACEUTICAL ACTIVE COMPOUNDS                                                                                  Russian version

The Pharmacological Active Compounds Laboratory was established in 2017 on the basis of NIICEL – branch of ICG SB RAS. The Head of Laboratory is PhD Solovieva Anastasiya

Laboratory main scientific direction is biological screening of synthetic and natural substances, composites based on them, as well as the development and study of materials for tissue engineering. Our laboratory programs include measuring cell functions, live cell imaging and in vivo experiments. Many of our laboratory projects are conducted in collaborations with physicist, chemists and biochemists.

Funding:

Russian Science Foundation

№ 14-14-0019 «Conjugates of octahedral molybdenum and rhenium cluster complexes with antibodies as promising agents for photodynamic therapy and bioimaging systems in oncology»

№18-75-10057 «Development and research of surface modifications of polycaprolactone nanofibres with biologically active molecules for the treatment of difficultly healing wounds in type 2 diabetes mellitus»

№ 18-75-10060 «Development and evaluation of the effectiveness of multimodal systems for targeted therapy of breast cancer»

 

Russian Foundation for Basic Research

№ 16-34-00542 «Investigation of the biocompatibility of luminescent and radiocontrast octahedral cluster complexes of tungsten»

18-315-00235 «The study of photoactive cluster metal complexes as agents for the elimination of stem tumor cells»

 

Research Group

 

Pozmogova T.N.

Junior Researcher, PhD student

 

Miroshnichenko S.M.

Junior Researcher

 

Shestopalov M.A.

PhD, Senior researcher

 

Ivanov A.Y.

PhD student, Assistant researcher

 

Vorotnikov Y.A.

PhD student, Assistant researcher

 

Vorotnikova N.A.

PhD student, Assistant researcher

 

Yaroslavtcev D.

Assistant researcher

 

Evtushok D.V. 

PhD student, Assistant researcher

 

Serov V.A.

Assistant researcher

 

Manahov D.

Senior researcher

 

Beklemishev A.B.

Senior researcher

 

Puhtina M.B.

 

Klyshova L.

Assistant researcher

   

 

Contacts: Timakova Street 2, 630060, Novosibirsk, Russia, e-mail: solovevaao@gmail.com, tel.: +79139060098

 


 

Selected Publications

2019 год

Y.A. Vorotnikov, T. N. Pozmogova, A.O. Solovieva, S.M. Miroshnichenko, E.V. Vorontsova, L.V. Shestopalova, Y.V. Mironov, M.A. Shestopalov, O.A. Efremova. Luminescent Silica Mesoparticles for Protein Transduction. Materials Science and Engineering: C. 2019,96, 530-538

R.R Zairov, A.O Solovieva, N.A Shamsutdinova, S.N Podyachev, M.A Shestopalov, T.N Pozmogova, S.M Miroshnichenko, A.Mustafina, A.A Karasik. Polyelectrolyte-coated ultra-small nanoparticles with Tb (III)-centered luminescence as cell labels with unusual charge effect on their cell internalization. Mater Sci Eng C Mater Biol Appl. 2019, 57, 414-433. doi.org/10.1016/j.msec.2018.10.084

A.A. Ivanov, D.I. Konovalov, T.N. Pozmogova, A.O. Solovieva, A.R. Melnikov, K.A. Brylev, N.V. Kuratieva, V.V. Yanshole, K. Kirakci, K. Lang, S.N. Cheltygmasheva, N. Kitamura, L.V. Shestopalova, Y.V. Mironov, M.A. Shestopalov. Water-soluble Re6-clusters with aromatic phosphine ligands – from synthesis to potential biomedical applications. Inorg. Chem. Front. 2019,6, 882-892 doi.org/10.1039/C8QI01216D

S. Miroshnichenko, V. Timofeeva, E. Permykova, S. Ershov, P. Kiryukhantsev-Korneev, E. Dvořaková, DV Shtansky, L. Zajíčková, A. Solovieva * and A. Manakhov *Plasma-Coated Polycaprolactone Nanofibers with Covalently Bonded Platelet-Rich Plasma Enhance Adhesion and Growth of Human Fibroblasts Nanomaterials 2019, 9(4), 637; https://doi.org/10.3390/nano9040637 IF=3.504

N. Vorotnikova, A. Alekseev, Y. Vorotnikov, D. Evtushok, Y.Molard, M Amela-Cortes, S Cordier, A. Smolentsev, CG. Burtonf, P. Kozhinc, P. Zhug, P. Tophamf, Y. Mironov,.M Bradley, O. Efremova, M. Shestopalov. Octahedral molybdenum cluster as a photoactive antimicrobial additive to a Fluoroplastic. Materials Science and Engineering: C Volume 105, 2019, 110150, doi.org/10.1016/j.msec.2019.110150

IS Taskaeva, NP Bgatova, AO Solovieva Autophagy in Hepatocellular Carcinoma-29 after Single or Combined Administration of Lithium Carbonate and Rapamycin. Cell and Tissue Biology 13 (5), 353-359

RS Dossymbekova, ZB Tungushbaev, KO Sharipov, YS Taskaev, AO Solovieva, NP Bgatova Гетерогенность и базальная аутофагия в клетках гепатокарциномы-29  Experimental Biology 78 (1), 140-150

M. B. Pykhtina, V. P. Romanov, S. M. Miroshnichenko, A. B. Beklemishev. Construction of a Pichia pastoris strain efficiently producing recombinant human granulocyte-colony stimulating factor (rhG-CSF) and study of its biological activity on bone marrow cells. Mol Biol Rep (2019). https://doi.org/10.1007/s11033-019-05169-9

2018

S.V. Fedorenko, S.L. Grechkina, A.R. Mukhametshina, A.O.Solovieva, T. N. Pozmogova, S.M. Miroshnichenko, A.Y. Alekseev, M.A. Shestopalov, K.V. KholinaIrek, R. Nizameev, A.R. Mustafina, Silica nanoparticles with Tb(III)-centered luminescence decorated by Ag0 as efficient cellular contrast agent with anticancer effect, Journal of Inorganic Biochemistry, 2018,182, 170-176, doi.org/10.1016/j.jinorgbio.2018.02.002 https://www.sciencedirect.com/science/article/pii/S0162013417307353, IF= 3.35, Q1

J.Elistratova, B.Akhmadeev, A. Gubaidullin, M.l A Shestopalov, A. Solovieva, K. Brylev, K.Kholin, I. Nizameev, I. Ismaev, M.l Kadirov, A. Mustafina, Structure optimization for enhanced luminescent and paramagnetic properties of hydrophilic nanomaterial based on heterometallic Gd-Re complexes, Materials & Design, 2018, 146, 49-56, doi.org/10.1016/j.matdes.2018.03.006, IF=4.498, Q=1

N.A. Vorotnikova, Y.A. Vorotnikov, I.N. Novozhilov, M.M. Syrokvashin, V.A. Nadolinny, N.V. Kuratieva, D.M. Benoit, Y.V. Mironov, R.I. Walton, G.J. Clarkson, N. Kitamura, A.J. Sutherland, M.A. Shestopalov, O.A. Efremova. 23-Electron Octahedral Molybdenum Cluster Complex [{Mo6I8}Cl6] INORG CHEM, 2018, No. 2, V. 52, pp. 811-820, IF=4,85. Q1

 

2017

A.A. Krasilnikova, A.O. Solovieva, A.A. Ivanov, K.E. Trifonova, T.N. Pozmogova, A.R. Tsygankova, A.I. Smolentsev, E.I. Kretov, D.S. Sergeevichev, M.A. Shestopalov, Y.V. Mironov, A.M. Shestopalov, A.F. Poveshchenko, L.V. Shestopalova. Comprehensive study of hexarhenium cluster complex Na4[{Re6Te8}(CN)6] – In terms of a new promising luminescent and X-ray contrast agent // Nanomedicine: NBM, 2017, V. 13, No.2, pp.755-763. doi: 10.1016/j.nano.2016.10.016. IF – 5,67, Q1

E.V. Svezhentseva, A.O. Solovieva, Y.A. Vorotnikov, O.G. Kurskaya, K.A. Brylev, A.R. Tsygankova, M.V. Edeleva, S.N. Gyrylova, N. Kitamura, O.A. Efremova, M.A. Shestopalov, Y.V. Mironov, A.M. Shestopalov. Water-soluble hybrid materials based on {Mo6X8}4+ (X = Cl, Br, I) cluster complexes and sodium polystyrene sulfonate // New J. Chem., 2017, V. 41, pp. 1670–1676, DOI: 10.1039/C6NJ03469A. IF – 3,277, Q2

J.G. Elistratova, K.A. Brylev, A.O. Solovieva, T.N. Pozmogova, A.R. Mustafina, L.V. Shestopalova, M.A. Shestopalov, V.V. Syakayev, A.A. Karasik, O.G. Sinyashin, Supporting effect of polyethylenimine on hexarhenium hydroxo cluster complex for cellular imaging applications // J. Photochem. Photobiol. A, 2017, V. 340, pp. 46-52, DOI: 10.1016/j.jphotochem. 2017.03.005. IF – 2.477, Q2

S.V. Fedorenko, A.R. Mustafina, A.R Mukhametshina, M.E. Jilkin, T.A. Mukhametzyanov, A.O. Solovieva, T.N. Pozmogova, L.V. Shestopalova, M.A. Shestopalov, K.V. Kholin, Y.N. Osin, O.G. Sinyashin. Cellular imaging by green luminescence of Tb(III)-doped aminomodified silica nanoparticles. Mater. Sci. Eng. C, 2017, V. 76, pp. 551-558, DOI: 10.1016/j.msec.2017.03.106. IF – 2.647, Q2

Anastasiya O. Solovieva, Kaplan Kirakci, Anton A. Ivanov, Pavel Kubát, Tatiana N. Pozmogova, Svetlana M. Miroshnichenko, Elena V. Vorontsova, Anton V. Chechushkov, Kristina E. Trifonova, Maria S. Fufaeva, Evgeniy I. Kretov, Yuri V. Mironov, Alexander F. Poveshchenko, Kamil Lang, and Michael A. Shestopalov. Singlet Oxygen Production and Biological Activity of Hexanuclear Chalcocyanide Rhenium Cluster Complexes [{Re6Q8}(CN)6]4– (Q = S, Se, Te) // Inorg. Chem., 2017, 56 (21), pp 13491–13499, DOI: 10.1021/acs.inorgchem.7b02212, IF= 4.8, Q1

Krasilnikova AA; Solovieva, AO; Ivanov, AA; Brylev, KA; Pozmogova, TN; Gulyaeva, MA; Kurskaya, OG; Alekseev, AY; Shestopalov, AM; Shestopalova, LV. A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes toxicity // Toxicology Research, 2017, vol. 6, 4, p. 554-560, DOI:10.1039/C7TX00083A, http://pubs.rsc.org/en/content/articlelanding/2017/tx/c7tx00083a#!divAbstract IF=1.97, Q3

D. V. Evtushok, N.A. Vorotnikova, V.A. Logvinenko, A. I. Smolentsev,  K.A. Brylev, P. E. Plyusnin, D. P. Pishchur, N. Kitamura, Y.V. Mironov, A.O. Solovieva, O. A. Efremova, M.A. Shestopalov.  Luminescent coordination polymers based on Ca2+ and octahedral cluster anions [{M6Cl8i}Cl-6(a)](2-) (M = Mo, W): synthesis and thermal stability studies, New Journal Of Chemistry, 2017, 41   (24), PP 14855-14861. DOI: 10.1039/c7nj02858j, http://pubs.rsc.org/en/content/articlehtml/2017/nj/c7nj02858j, IF=3.27, Q2  

A.O. Solovieva , S Miroshnichenko, A Kovalskii, E Permyakova,  Z Popov, E  Dvořáková, P Kiryukhantsev-Korneev,  A Obrosov, J Polčak, L Zajíčková, D V. Shtansky and A Manakhov Immobilization of Platelet-Rich Plasma onto COOH Plasma-Coated PCL Nanofibers Boost Viability and Proliferation of Human Mesenchymal Stem Cells Polymers 2017, 9(12), 736; doi:10.3390/polym9120736. IF= 3.4. Q1

J. Elistratova, B. Akhmadeev, A. Gubaidullin, M. A. Shestopalov, A. Solovieva, K. Brylev, K. Kholin, I. Nizameev, I. Ismaev, M. Kadirov, A. Mustafina, Structure optimization for enhanced luminescent and paramagnetic properties of hydrophilic nanomaterial based on heterometallic Gd-Re complexes. Materials & Design (2017), doi:10.1016/ j.matdes.2018.03.006, IF=4.4, Q1

Vorontsova E., Solovieva A. IMAGE ANALYSIS METHODS IN HIGH-CONTENT SCREENING FOR PHENOTYPIC DRUG DISCOVERY 2017 International Multi-Conference on Engineering, Computer and Information Science (SIBIRCON) conference proceedings. 2017. P. 575

Bgatova N.P., Gavrilova Yu.S., Lykov A.P., Solovieva A.O., Makarova V.V., Borodin Yu.I., Konenkov V.I. apoptosis and autophagy in hepatocarcinoma cells induced by different forms of lithium salts. Cell and Tissue Biology. 2017. Т. 11. № 4. С. 261-267.

Cellular imaging by green luminescence of Tb(III)-doped aminomodified silica nanoparticles. S.V. Fedorenko, A.R. Mustafina, A.R Mukhametshina, M.E. Jilkin, T.A. Mukhametzyanov, A.O. Solovieva, T.N. Pozmogova, L.V. Shestopalova, M.A. Shestopalov, K.V. Kholin, Y.N. Osin, O.G. Sinyashin. // Mater. Sci. Eng. C, 2017, V. 76, pp. 551-558, DOI: 10.1016/j.msec.2017.03.106.

Supporting effect of polyethylenimine on hexarhenium hydroxo cluster complex for cellular imaging applications. J.G. Elistratova, K.A. Brylev, A.O. Solovieva, T.N. Pozmogova, A.R. Mustafina, L.V. Shestopalova, M.A. Shestopalov, V.V. Syakayev, A.A. Karasik, O.G. Sinyashin // Photochem. Photobiol. A, 2017, V. 340, pp. 46-52, DOI: 10.1016/j.jphotochem.2017.03.005.

Water-soluble hybrid materials based on {Mo6X8}4+ (X = Cl, Br, I) cluster complexes and sodium polystyrene sulfonate. E.V. Svezhentseva, A.O. Solovieva, Y.A. Vorotnikov, O.G. Kurskaya, K.A. Brylev, A.R. Tsygankova, M.V. Edeleva, S.N. Gyrylova, N. Kitamura, O.A. Efremova, M.A. Shestopalov, Y.V. Mironov, A.M. Shestopalov // New J. Chem., 2017, V. 41, pp. 1670–1676, DOI: 10.1039/C6NJ03469A.

Comprehensive study of hexarhenium cluster complex Na4[{Re6Te8}(CN)6] – In terms of a new promising luminescent and X-ray contrast agent. A.A. Krasilnikova, A.O. Solovieva, A.A. Ivanov, K.E. Trifonova, T.N. Pozmogova, A.R. Tsygankova, A.I. Smolentsev, E.I. Kretov, D.S. Sergeevichev, M.A. Shestopalov, Y.V. Mironov, A.M. Shestopalov, A.F. Poveshchenko, L.V. Shestopalova. // Nanomedicine: NBM, 2017, V. 13, No.2, pp.755-763. doi: 10.1016/j.nano.2016.10.016

A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes' toxicity. A.A. Krasilnikova, A.O. Solovieva, A.A. Ivanov, K.A. Brylev, T.N. Pozmogova, M.A. Gulyaeva, O.G. Kurskaya, A.Y. Alekseev, A.M. Shestopalov, L.V. Shestopalova, A.F. Poveshchenko, O.A. Efremova, Y.V. Mironov and M.A. Shestopalov // Toxicol. Res., 2017,6, 554-560. doi: 10.1039/C7TX00083A

Nanosized mesoporous metal–organic framework MIL-101 as a nanocarrier for photoactive hexamolybdenum cluster compounds. A.M. Cheplakova, A.O. Solovieva, T.N. Pozmogova, Y.A. Vorotnikov, K.A. Brylev, N.A. Vorotnikova, E.V. Vorontsova, Y.V. Mironov, A.F. Poveshchenko, K.A. Kovalenko, M.A. Shestopalov. // J. Inorg. Biochem., 2017, V. 166, pp. 100-107, doi: 10.1016/j.jinorgbio.2016.11.014

 

2016

1. A.O. Solovieva, Y.A. Vorotnikov, K.E. Trifonova, O.A. Efremova, A.A. Krasilnikova, K.A. Brylev, E.V. Vorontsova, P.A. Avrorov, L.V. Shestopalova, A.F. Poveshchenko, Y.V. Mironov M.A. Shestopalov. Cellular internalisation, bioimaging and dark and photodynamic cytotoxicity of silica nanoparticles doped by {Mo6I8}4+ metal cluster // J. Mater. Chem. B., 2016, No. 28, V. 4, pp. 4839-4846 doi: 10.1039/C6TB00723F. IF – 4,87, Q1

2. A.A. Krasilnikova, A.O. Solovieva, K.E. Trifonova, K.A. Brylev, A.A. Ivanov, S.-J. Kim, M.A. Shestopalov, M.S. Fufaeva, A.M. Shestopalov, Y.V. Mironov, A.F. Poveshchenko, L.V. Shestopalova. Cellular internalization and morphological analysis after intravenous injection of a highly hydrophilic octahedral rhenium cluster complex – a new promising X-ray contrast agent // Contrast Media Mol. Imaging, 2016, V. 11, pp. 459-466, doi: 10.1002/cmmi.1707. IF – 3.286. Q1

3. A.M. Cheplakova, A.O. Solovieva, T.N. Pozmogova, Y.A. Vorotnikov, K.A. Brylev, N.A. Vorotnikova, E.V. Vorontsova, Y.V. Mironov, A.F. Poveshchenko, K.A. Kovalenko, M.A. Shestopalov. Nanosized mesoporous metal–organic framework MIL-101 as a nanocarrier for photoactive hexamolybdenum cluster compounds // J. Inorg. Biochem., 2017, V. 166, pp. 100-107, doi: 10.1016/j.jinorgbio.2016.11.014. IF – 3,2. Q2