LABORATORY OF PHARMACEUTICAL ACTIVE COMPOUNDS                                                                                  Russian version

The Laboratory of Pharmaceutical Active Compounds was established in 2017 on the basis of NIIKEL. Scientific interests are the development of screening of biological effects of various compounds.

The main areas of work of the laboratory

Screening of synthesized compounds, determination of their cytotoxicity, studies of mechanism and kinetics of intracellular penetration and excretion, intracellular distribution. Determination of the specific activity of synthesized compounds, acute and chronic toxicity in vivo. Pathomorphological studies

 

The laboratory is headed by Solovieva Anastasia Olegovna, PhD.

 

The work of the group is supported by grants:

RSF № 14-14-0019 «Conjugates of octahedral molybdenum and rhenium cluster complexes with antibodies as promising agents for photodynamic therapy and bioimaging systems in oncology»

RFFR № №16-34-00542 «Investigation of the biocompatibility of luminescent and radiocontrast octahedral cluster complexes of tungsten»

Research Group

 

Pozmogova T.N.

Junior Researcher, PhD student

 

Miroshnichenko S.M.

Junior Researcher

 

Shestopalov M.A.

PhD, Senior researcher

 

Brylev K.A.

PhD, Junior Researcher

 

Vorotnikov Y.A.

PhD student, Assistant researcher

 

Vorotnikova N.A.

PhD student, Assistant researcher

 

Mironov Y.V.

PhD, Junior Researcher

 

Evtushok D.V. 

PhD student, Assistant researcher

 

Ivanov A.Y.

PhD student, Assistant researcher

 

Rodniy A.Y.

student, Assistant researcher

 

Vorontcova E.V.

PhD, Junior Researcher

 

Yaroslavtcev D.

Assistant researcher

 

Evsukova V.S.

Assistant researcher

   

 

Contacts: Timakova Street 2, 630060, Novosibirsk, Russia, e-mail: solovevaao@gmail.com, tel.: +79139060098

 


 

Selected Publications

2018

S.V. Fedorenko, S.L. Grechkina, A.R. Mukhametshina, A.O.Solovieva, T. N. Pozmogova, S.M. Miroshnichenko, A.Y. Alekseev, M.A. Shestopalov, K.V. KholinaIrek, R. Nizameev, A.R. Mustafina, Silica nanoparticles with Tb(III)-centered luminescence decorated by Ag0 as efficient cellular contrast agent with anticancer effect, Journal of Inorganic Biochemistry, 2018,182, 170-176, doi.org/10.1016/j.jinorgbio.2018.02.002 https://www.sciencedirect.com/science/article/pii/S0162013417307353, IF= 3.35, Q1

J.Elistratova, B.Akhmadeev, A. Gubaidullin, M.l A Shestopalov, A. Solovieva, K. Brylev, K.Kholin, I. Nizameev, I. Ismaev, M.l Kadirov, A. Mustafina, Structure optimization for enhanced luminescent and paramagnetic properties of hydrophilic nanomaterial based on heterometallic Gd-Re complexes, Materials & Design, 2018, 146, 49-56, doi.org/10.1016/j.matdes.2018.03.006, IF=4.498, Q=1

N.A. Vorotnikova, Y.A. Vorotnikov, I.N. Novozhilov, M.M. Syrokvashin, V.A. Nadolinny, N.V. Kuratieva, D.M. Benoit, Y.V. Mironov, R.I. Walton, G.J. Clarkson, N. Kitamura, A.J. Sutherland, M.A. Shestopalov, O.A. Efremova. 23-Electron Octahedral Molybdenum Cluster Complex [{Mo6I8}Cl6] INORG CHEM, 2018, No. 2, V. 52, pp. 811-820, IF=4,85. Q1

 

2017

A.A. Krasilnikova, A.O. Solovieva, A.A. Ivanov, K.E. Trifonova, T.N. Pozmogova, A.R. Tsygankova, A.I. Smolentsev, E.I. Kretov, D.S. Sergeevichev, M.A. Shestopalov, Y.V. Mironov, A.M. Shestopalov, A.F. Poveshchenko, L.V. Shestopalova. Comprehensive study of hexarhenium cluster complex Na4[{Re6Te8}(CN)6] – In terms of a new promising luminescent and X-ray contrast agent // Nanomedicine: NBM, 2017, V. 13, No.2, pp.755-763. doi: 10.1016/j.nano.2016.10.016. IF – 5,67, Q1

E.V. Svezhentseva, A.O. Solovieva, Y.A. Vorotnikov, O.G. Kurskaya, K.A. Brylev, A.R. Tsygankova, M.V. Edeleva, S.N. Gyrylova, N. Kitamura, O.A. Efremova, M.A. Shestopalov, Y.V. Mironov, A.M. Shestopalov. Water-soluble hybrid materials based on {Mo6X8}4+ (X = Cl, Br, I) cluster complexes and sodium polystyrene sulfonate // New J. Chem., 2017, V. 41, pp. 1670–1676, DOI: 10.1039/C6NJ03469A. IF – 3,277, Q2

J.G. Elistratova, K.A. Brylev, A.O. Solovieva, T.N. Pozmogova, A.R. Mustafina, L.V. Shestopalova, M.A. Shestopalov, V.V. Syakayev, A.A. Karasik, O.G. Sinyashin, Supporting effect of polyethylenimine on hexarhenium hydroxo cluster complex for cellular imaging applications // J. Photochem. Photobiol. A, 2017, V. 340, pp. 46-52, DOI: 10.1016/j.jphotochem. 2017.03.005. IF – 2.477, Q2

S.V. Fedorenko, A.R. Mustafina, A.R Mukhametshina, M.E. Jilkin, T.A. Mukhametzyanov, A.O. Solovieva, T.N. Pozmogova, L.V. Shestopalova, M.A. Shestopalov, K.V. Kholin, Y.N. Osin, O.G. Sinyashin. Cellular imaging by green luminescence of Tb(III)-doped aminomodified silica nanoparticles. Mater. Sci. Eng. C, 2017, V. 76, pp. 551-558, DOI: 10.1016/j.msec.2017.03.106. IF – 2.647, Q2

Anastasiya O. Solovieva, Kaplan Kirakci, Anton A. Ivanov, Pavel Kubát, Tatiana N. Pozmogova, Svetlana M. Miroshnichenko, Elena V. Vorontsova, Anton V. Chechushkov, Kristina E. Trifonova, Maria S. Fufaeva, Evgeniy I. Kretov, Yuri V. Mironov, Alexander F. Poveshchenko, Kamil Lang, and Michael A. Shestopalov. Singlet Oxygen Production and Biological Activity of Hexanuclear Chalcocyanide Rhenium Cluster Complexes [{Re6Q8}(CN)6]4– (Q = S, Se, Te) // Inorg. Chem., 2017, 56 (21), pp 13491–13499, DOI: 10.1021/acs.inorgchem.7b02212, IF= 4.8, Q1

Krasilnikova AA; Solovieva, AO; Ivanov, AA; Brylev, KA; Pozmogova, TN; Gulyaeva, MA; Kurskaya, OG; Alekseev, AY; Shestopalov, AM; Shestopalova, LV. A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes toxicity // Toxicology Research, 2017, vol. 6, 4, p. 554-560, DOI:10.1039/C7TX00083A, http://pubs.rsc.org/en/content/articlelanding/2017/tx/c7tx00083a#!divAbstract IF=1.97, Q3

D. V. Evtushok, N.A. Vorotnikova, V.A. Logvinenko, A. I. Smolentsev,  K.A. Brylev, P. E. Plyusnin, D. P. Pishchur, N. Kitamura, Y.V. Mironov, A.O. Solovieva, O. A. Efremova, M.A. Shestopalov.  Luminescent coordination polymers based on Ca2+ and octahedral cluster anions [{M6Cl8i}Cl-6(a)](2-) (M = Mo, W): synthesis and thermal stability studies, New Journal Of Chemistry, 2017, 41   (24), PP 14855-14861. DOI: 10.1039/c7nj02858j, http://pubs.rsc.org/en/content/articlehtml/2017/nj/c7nj02858j, IF=3.27, Q2  

A.O. Solovieva , S Miroshnichenko, A Kovalskii, E Permyakova,  Z Popov, E  Dvořáková, P Kiryukhantsev-Korneev,  A Obrosov, J Polčak, L Zajíčková, D V. Shtansky and A Manakhov Immobilization of Platelet-Rich Plasma onto COOH Plasma-Coated PCL Nanofibers Boost Viability and Proliferation of Human Mesenchymal Stem Cells Polymers 2017, 9(12), 736; doi:10.3390/polym9120736. IF= 3.4. Q1

J. Elistratova, B. Akhmadeev, A. Gubaidullin, M. A. Shestopalov, A. Solovieva, K. Brylev, K. Kholin, I. Nizameev, I. Ismaev, M. Kadirov, A. Mustafina, Structure optimization for enhanced luminescent and paramagnetic properties of hydrophilic nanomaterial based on heterometallic Gd-Re complexes. Materials & Design (2017), doi:10.1016/ j.matdes.2018.03.006, IF=4.4, Q1

Vorontsova E., Solovieva A. IMAGE ANALYSIS METHODS IN HIGH-CONTENT SCREENING FOR PHENOTYPIC DRUG DISCOVERY 2017 International Multi-Conference on Engineering, Computer and Information Science (SIBIRCON) conference proceedings. 2017. P. 575

Bgatova N.P., Gavrilova Yu.S., Lykov A.P., Solovieva A.O., Makarova V.V., Borodin Yu.I., Konenkov V.I. apoptosis and autophagy in hepatocarcinoma cells induced by different forms of lithium salts. Cell and Tissue Biology. 2017. Т. 11. № 4. С. 261-267.

Cellular imaging by green luminescence of Tb(III)-doped aminomodified silica nanoparticles. S.V. Fedorenko, A.R. Mustafina, A.R Mukhametshina, M.E. Jilkin, T.A. Mukhametzyanov, A.O. Solovieva, T.N. Pozmogova, L.V. Shestopalova, M.A. Shestopalov, K.V. Kholin, Y.N. Osin, O.G. Sinyashin. // Mater. Sci. Eng. C, 2017, V. 76, pp. 551-558, DOI: 10.1016/j.msec.2017.03.106.

Supporting effect of polyethylenimine on hexarhenium hydroxo cluster complex for cellular imaging applications. J.G. Elistratova, K.A. Brylev, A.O. Solovieva, T.N. Pozmogova, A.R. Mustafina, L.V. Shestopalova, M.A. Shestopalov, V.V. Syakayev, A.A. Karasik, O.G. Sinyashin // Photochem. Photobiol. A, 2017, V. 340, pp. 46-52, DOI: 10.1016/j.jphotochem.2017.03.005.

Water-soluble hybrid materials based on {Mo6X8}4+ (X = Cl, Br, I) cluster complexes and sodium polystyrene sulfonate. E.V. Svezhentseva, A.O. Solovieva, Y.A. Vorotnikov, O.G. Kurskaya, K.A. Brylev, A.R. Tsygankova, M.V. Edeleva, S.N. Gyrylova, N. Kitamura, O.A. Efremova, M.A. Shestopalov, Y.V. Mironov, A.M. Shestopalov // New J. Chem., 2017, V. 41, pp. 1670–1676, DOI: 10.1039/C6NJ03469A.

Comprehensive study of hexarhenium cluster complex Na4[{Re6Te8}(CN)6] – In terms of a new promising luminescent and X-ray contrast agent. A.A. Krasilnikova, A.O. Solovieva, A.A. Ivanov, K.E. Trifonova, T.N. Pozmogova, A.R. Tsygankova, A.I. Smolentsev, E.I. Kretov, D.S. Sergeevichev, M.A. Shestopalov, Y.V. Mironov, A.M. Shestopalov, A.F. Poveshchenko, L.V. Shestopalova. // Nanomedicine: NBM, 2017, V. 13, No.2, pp.755-763. doi: 10.1016/j.nano.2016.10.016

A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes' toxicity. A.A. Krasilnikova, A.O. Solovieva, A.A. Ivanov, K.A. Brylev, T.N. Pozmogova, M.A. Gulyaeva, O.G. Kurskaya, A.Y. Alekseev, A.M. Shestopalov, L.V. Shestopalova, A.F. Poveshchenko, O.A. Efremova, Y.V. Mironov and M.A. Shestopalov // Toxicol. Res., 2017,6, 554-560. doi: 10.1039/C7TX00083A

Nanosized mesoporous metal–organic framework MIL-101 as a nanocarrier for photoactive hexamolybdenum cluster compounds. A.M. Cheplakova, A.O. Solovieva, T.N. Pozmogova, Y.A. Vorotnikov, K.A. Brylev, N.A. Vorotnikova, E.V. Vorontsova, Y.V. Mironov, A.F. Poveshchenko, K.A. Kovalenko, M.A. Shestopalov. // J. Inorg. Biochem., 2017, V. 166, pp. 100-107, doi: 10.1016/j.jinorgbio.2016.11.014

 

2016

1. A.O. Solovieva, Y.A. Vorotnikov, K.E. Trifonova, O.A. Efremova, A.A. Krasilnikova, K.A. Brylev, E.V. Vorontsova, P.A. Avrorov, L.V. Shestopalova, A.F. Poveshchenko, Y.V. Mironov M.A. Shestopalov. Cellular internalisation, bioimaging and dark and photodynamic cytotoxicity of silica nanoparticles doped by {Mo6I8}4+ metal cluster // J. Mater. Chem. B., 2016, No. 28, V. 4, pp. 4839-4846 doi: 10.1039/C6TB00723F. IF – 4,87, Q1

2. A.A. Krasilnikova, A.O. Solovieva, K.E. Trifonova, K.A. Brylev, A.A. Ivanov, S.-J. Kim, M.A. Shestopalov, M.S. Fufaeva, A.M. Shestopalov, Y.V. Mironov, A.F. Poveshchenko, L.V. Shestopalova. Cellular internalization and morphological analysis after intravenous injection of a highly hydrophilic octahedral rhenium cluster complex – a new promising X-ray contrast agent // Contrast Media Mol. Imaging, 2016, V. 11, pp. 459-466, doi: 10.1002/cmmi.1707. IF – 3.286. Q1

3. A.M. Cheplakova, A.O. Solovieva, T.N. Pozmogova, Y.A. Vorotnikov, K.A. Brylev, N.A. Vorotnikova, E.V. Vorontsova, Y.V. Mironov, A.F. Poveshchenko, K.A. Kovalenko, M.A. Shestopalov. Nanosized mesoporous metal–organic framework MIL-101 as a nanocarrier for photoactive hexamolybdenum cluster compounds // J. Inorg. Biochem., 2017, V. 166, pp. 100-107, doi: 10.1016/j.jinorgbio.2016.11.014. IF – 3,2. Q2