LABORATORY OF CLINICAL IMMUNOGENETICS                                                                   Russian version

 

Main Research Field   

Populational studies of the distribution of immune response genes

Development of immunogenetic methods of early disease diagnosis and prognosis

Molecular mechanisms  realization of the immune response gene functions in normal and pathological conditions

The laboratory has arsenal of unique laboratory equipment that enables high-precision testing of biological active molecules at minimum time. Applied molecular biology techniques: genotyping, PCR-diagnostics, flow cytometry, Elisa etc.  These methods can be used, and for scientific purposes, and in medical practice.

Laboratory is managed by the member of Russian Academy of Science, Professor Vladimir I. Konenkov.  He is a prominent leader in the field of immunogenetic bases of human pathology.

The principal areas of his research activity:

- genetic regulation of differentiation, activation and proliferation of cells of the immune system; integrative role of the immune system in collaboration with the major regulatory systems of the body;

- genetic basis of immune system response to the specific and nonspecific factors of external environment at the individual and population levels;

- cellular and molecular-genetic mechanisms of development of immune-mediated human diseases.

 

One of the first in Russia Professor V. Konenkov described the phenomenon of cytokine activation associated with entering into circulation and its essential role in human autoimmune processes.

These data  had been given further support to notion of the key role of histocompatibility molecules biogenesis in the processes of realization of functions of the immune system. For the first time it has been proven that the chance of developing encephalitis after the bite of an infected tick is associated with the allelic variants of HLA genes.

Some allelic variants of the genes of cytokines associated with susceptibility and resistance to the development of AIDS and hepatitis C were identified and ability to predict fast and slow development of AIDS in HIV-infected patients was proven.

Professor V. Konenkov oversaw the development and implementation of automated expert estimations of human immune system states and establishment of immunogenetic ensure the transplantation of organs and tissues in the Siberian region.

 

Research Staff

Dr. Alla V. Shevchenko, Leading researcher, Dr. Sci. (Biol.)

Dr. A. Shevchenko graduated from cytology and genetics Faculty of Tomsk State University in 1986. She Worked in State Research Center of Virology and Biotechnology VECTOR, SibEnzyme LTD, Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, since 2005 in Research Institute of Clinical and Experimental Lymphology - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences. Candidate and doctoral dissertations was defended in specialty «Clinical immunology, allergology»

His current research interests are related to immunogenetics features of development of multifactorial diseases.

She is an author of 135 articles in peer-reviewed journals.

Dr. Viktor F. Prokof’iev, Leading Researcher, PhD

Dr. V. Prokof’iev graduated from the Medical Faculty of the Novosibirsk State Medical Institute in 1972. Since 1975, after finishing graduate school, he worked as an assistant of the Department of normal anatomy of the Novosibirsk Medical Institute. Since 1981, he works as a leading researcher in the Laboratory of Clinical Immunogenetics at first in the Institute of Fundamental and Clinical Immunology, and since 2005 - in the Institute of Clinical and Experimental lymphology.

His current research interests include the Population and Clinical Immunogenetics human, gene networks and modeling of stochastic processes. He is a Specialist in the development of automated systems and methods for early diagnosis and prognosis of human multifactorial diseases based on bioinformatics analysis of the genome of the cytokine.

He is an author of 118 articles in peer-reviewed journals.

Dr. Natalya N. Svechnikova, Leading Researcher, MD, PhD

Dr. N. Svechnikova graduated from the Pediatric Faculty of the Novosibirsk State Medical Institute in 1976, completed training in clinical residency. She defended candidate and doctoral dissertations in specialty "skin and venereal disease".

Her scientific interests are connected with manifestations of skin diseases in diseases of the digestive system and endocrine system, histological changes of the skin and the lymphatic system in dermatoses.

Provides advice of the doctor-dermatovenerologist. In practical medical activity uses the methods of endoecological rehabilitation.

She is an author of 134 articles in peer-reviewed journals.

 

 

Dr. Nikolay B. Orlov, Senior Researcher, PhD

Dr. N. Orlov graduated from the Medical Faculty of the Novosibirsk State Medical Institute in 1980. Since 1981, after graduating from clinical residency, he works first as a junior and later as a senior researcher at the Scientific Research Institute for Fundamental and Clinical Immunology. Since 2005 he works at the Research Institute of Clinical and Experimental Lymphology.

His current research interests include the X map technology, flow fluorometry. He is a Specialist in the Production of cytokines and chemokines for various diseases and pathological conditions, Methods of infection diagnosis, the role of infections in the pathogenesis of autoimmune diseases.

He is an author of 34 articles in peer-reviewed journals.

 

Selected Publications

2017

1. Shevchenko A.V., Prokofyev V.F., Korolev M.A., Banshchikova N.E., Konenkov V.I. Polymorphism in the regulatory regions –С2578A and +C936T of the vascular endothelial growth factor (VEGF-A) gene in Russian women with rheumatoid arthritis // Terapevticheskiy arkhiv. - 2017.-Vol.89.- N.5. - P.60-64.

2. Klimontov V.V., Tyan N.V., Orlov N.B., Shevchenko A.V., Prokofiev V.F., Myakina N.E., Bulumbaeva D.M., Konenkov V.I. Association of Serum Levels and Gene Polymorphism of Vascular Endothelium Growth Factor With Ischemic Heart Disease in Type 2 Diabetic Patients // Kardiologiya. - 2017.- Vol.57.- N.5.- P. 17-22.

3. Chernykh V., Trunov A., Shevchenko A., Prokofiev V. Vascular Endothelial Growth Factor, Matrix Metalloproteinases and Tumor Necrosis Factor-α Complex Genetic Polymorphisms in Age-Related Macular Degeneration // Ophthalmic Res 2017;58(suppl 1):1–2.

2016

1. Shevchenko A.V. , Konenkov V.I., Prokof'ev V.F., Poveshchenko O.V., Lykov A.P., Bondarenko N.A., Kim I.I. Constitutional basis of the levels of spontaneous and induced production of cytokines TNA-a, IL-1β, IL-4, IL-6 and IL-10 in healthy individuals of the european population of Russia // Immunology. – 2016. - Vol. 37, No. 5. - P. 232-238. Russian.

2. Shevchenko A. V., Prokof’ev V. F., Konenkov V. I., Chernykh V. V., Eremina A. V., Dudnikova L. V., Kashkin, N. Yu., Trunov A. N. Cytokine gene polymorphisms in patients with age-related macular degeneration // Vestnik of ophthalmology. - 2016. - Vol. 132, No. 2. - P. 8-13. Russian.

3. Shevchenko A.V., Konenkov V. I., Prokof’ev V. F., Ragino Y. I., Cherniavsky A. M., Voevoda M. I.
The associating of the number of homozygous genotypes gene regulation of inflammation, destruction and angiogenesis laboratory markers of atherosclerosis in men with stable angina // Cardiology. - 2016. - Vol. 56, No. 3. -P. 5-11. Russian.

4.Prokof’ev V. F., Shevchenko A. V., Konenkov V. I. Analysis of cytokine genome for female infertility // In the book: “Lymphology: from fundamental research to medical technology.” Materials of XII international conference, dedicated to the 25th anniversary of the research Institute of clinical and experimental lymphology. - Novosibirsk, 2016. - P. 212-215. Russian.

2015 - 2012

1: Shevchenko AV, Konenkov VI, Korolev MA, Ubshaeva YB, Prokofiev VF. [Matrix metalloproteinase 2, 3, and 9 gene polymorphisms in women with rheumatoid arthritis]. Ter Arkh. 2015;87(12):36-40. Russian.

 2: Shevchenko AV, Doronin BM, Kuznetsova VB, Amstislavskaya TG. [The lipid profile and psychometric assessments in patients with psychosomatic illnesses and chronic cerebral ischemia]. Zh Nevrol Psikhiatr Im S S Korsakova. 2015;115(12. Vyp. 2. Insul't):43-47. Russian

3: Shevchenko AV, Konenkov VI, Prokof'ev VF, Pokushalov EA. [Analysis of genotype combinations at the polymorphic points of the promoter regions of the genes of three matrix metalloproteinases and the gene of vascular endothelial growth factor (VEGF) in patients with history of acute myocardial infarction]. Ter Arkh. 2014;86(4):19-24. Russian

4:  Shevchenko AV, Konenkov VI, Garbukov EIu, Stakheeva MN. [Associating of polymorphism in the promoter regions of genes of metalloproteinase (MMP2, MMP3, MMP9) with options of the clinical course of breast cancer in Russian women]. Vopr Onkol. 2014;60(5):630-5. Russian.

5: Konenkov VI, Korolev MA, Shevchenko AV, Prokofyev VF, Ubshaeva YB, Sokolova OS, Letyagina EA, Dyubanova GA. [Genetic factors of angiogenic dysregulation in women with rheumatoid arthritis]. Ter Arkh. 2013;85(5):16-23. Russian

6: Konenkov VI, Prokof'ev VF, Shevchenko AV, Cherniavskiĭ AM, Karas'kov AM. [Age and sexual changes structure of genes cytokines networks in Russian population]. Vestn Ross Akad Med Nauk. 2013;(9):15-21. Russian

7: Konenkov VI, Shevchenko AV, Prokof'ev VF, Maksimov VN. [Complex of genotypes of cytokines as a genetic factor of risk of development of myocardial infarction of in Europien population of Russia men]. Kardiologiia. 2012;52(7):22-9. Russian.

8: Shevchenko AV, Konenkov VI, Garbukov EIu, Stakheeva MN. [Polymorphism of regulatory regions of growth factor gene of vascular endothelium VEGFA in breast cancer patients with family history]. Vopr Onkol. 2012;58(6):773-6. Russian.

Selected Conference Presentations 

2016 

1. Prokof'ev V.F., Shevchenko A.V., Korolev M.A., Konenkov V.I.  Using the techniques of stochastic modeling and inhomogeneous sequential pattern recognition procedure for the prediction the development of polygenic diseases. // The International Symposium “Systems Biology and Biomedicine (SBioMed-2016)”. Abstract Book. - Novosibirsk, Russia, August 30-31, 2016. – P. 85.

2. Shevchenko A.V., Prokof`ev V.F., Konenkov V.I. Commonability of the combinations of polymorphic regulatory sites in the cytokine genes in pathogenetically diverse diseases in women. // The International Symposium “Systems Biology and Biomedicine (SBioMed-2016)”. Abstract Book. - Novosibirsk, Russia, August 30-31, 2016. – P. 95.

3. Shevchenko A.V., Prokof`ev V.F., Konenkov V.I., Eremina A.V., Chernich V.V. Associativity of some genetic factors with development of AMD. // The All-Russia scientific - practical conference with online-translation «Basic researches in ophthalmology»  under the aegis  of ophthalmologist  association  of Russia. Novosibirsk, 3 november 2016.

2015

1. Tyan N. V. Shevchenko A. V., Prokof’ev V. F., Bulumbaeva D. M., Polezhaev Y. V., Klimontov V. V., Konenkov, V. I., Analysis of polymorphism of genes of interleukins, growth factors and matrix metalloproteinases in patients with diabetes mellitus type 2 with ischemic heart disease // Diabetes in the XXI century – the time of unification efforts: the VII Russian diabetes Congress. The book of abstracts. – Moscow, 24-27 February 2015. – M.: up Print, 2015. – P. 47.
2. Fazullina O. N., Klimontov V. V., Shevchenko A. V., Prokof’ev V. F., Konenkov V. I. Combinations of gene variants of cytokines and matrix metalloproteinases associated with a decrease in mineral bone density in women with diabetes type 2 diabetes. // Diabetes in the XXI century – the time of unification efforts: the VII Russian diabetes Congress. The book of abstracts. M., 24-27 Feb 2015. – M.: up Print, 2015. – P. 332.

 

 

 

Contacts

Galushchak Street 11, Novosibirsk, Russia

Tel.:  +7-383-335-95-31

E-mail: vikonenkov@gmail.com